Secretin Receptor

SCTR

Secretin receptor (SCTR) is a G protein-coupled receptor (GPCR) which binds secretin. The secretin receptor has a 427-amino acid sequence and a molecular weight of 48,696 Da. The secretin receptor is related structurally to the receptors for VIP, parathyroid hormone (PTH), and calcitonin. Secretin receptors are expressed in the basolateral domain of several cell types. Secretin is a member of the secretin-glucagon family and is secreted by S cells of the duodenum in the small intestine. In addition to regulating the pH of the duodenal content by the control of gastric acid secretion, secretin regulates the secretion of bicarbonate ions into the duodenum from the epithelia lining the pancreatic and biliary ducts. Secretin has also been considered as a neuropeptide hormone since it is also expressed in the central nervous system (CNS). Recent evidence has indicated that secretin has pleiotropic effects in several organ systems (including the biliary epithelium) and has been termed a neuroendocrine hormone.

Secretin Receptor Related Products (10):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P1465

Human secretin		99.17%
Human secretin is a 27-amino acid residue C-terminally amidated peptide, which acts on human secretin receptors.

HY-P1244A

Secretin (33-59), rat TFA		98.87%
Secretin (33-59), rat (TFA) is a 27-aa peptide, which acts on secretin receptor, and enhances the secretion of bicarbonate, enzymes, and K⁺ from the pancreas.

HY-109538

Secretin (swine)		98.88%
Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism.

HY-P1465A

Human secretin TFA		98.62%
Human secretin TFA is a 27-amino acid residue C-terminally amidated peptide, which acts on human secretin receptors.

HY-P1784A

Secretin, canine TFA		99.85%
ecretin, canine TFA is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Secretin, canine TFA can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.

HY-19106

MCI-727 free base
MCI-727 free base is an orally active anti-ulcer agent. MCI-727 free base can increase the plasma secretin concentration in rats and dogs. MCI-727 free base can also stimulate the exocrine function of the pancreas in rats by promoting the release of endogenous secretin, and exert preventive and therapeutic effects on mild acute pancreatitis. MCI-727 free base can be used in the research of ulcer-related diseases.

HY-P1244

Secretin (33-59), rat
Secretin (33-59), rat is a 27-aa peptide, acts on secretin receptor, enhances the secretion of bicarbonate, enzymes, and K⁺ from the pancreas.

HY-P1784

Secretin, canine
Secretin, canine is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Secretin, canine can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.

HY-P1781A

Peptide C105Y TFA
Peptide C105Y TFA, a synthetic and cell-penetrating peptide based on the amino acid sequence corresponding to residues 359-374 of α1-antitrypsin, enhances gene expression from DNA nanoparticles.

HY-109538R

Secretin (swine) (Standard)
Secretin (swine) (Standard) is the analytical standard of Secretin (swine). This product is intended for research and analytical applications. Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism.

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